a tool for identifying drug-targetable redox-active disulphides

Lytic switch protein BZLF1

Intermolecular

Cysteine 188 of HLA class I histocompatibility antigen, B alpha chain and cysteine 171

A redox-regulated disulphide may form between cysteine 188 of HLA class I histocompatibility antigen, B alpha chain and cysteine 171 of Lytic switch protein BZLF1 (164 and 3 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

38

PDB code

Structure name

hla-b*44:03 in complex with epstein-barr virus bzlf1-derived peptide (residues 169-180)

Structure deposition date

2013-03-20

Thiol separation (Å)

9

Half-sphere exposure sum ?

75

Minimum pK_a ?

11

% buried

nan

Peptide A name

HLA class I histocompatibility antigen, B alpha chain

Peptide B name

Lytic switch protein BZLF1

Peptide A accession

Peptide B accession

Peptide A residue number

188

Peptide B residue number

171

Ligandability

Cysteine 188 of HLA class I histocompatibility antigen, B alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of Lytic switch protein BZLF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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